- Tramadol's structural formula :
- The molecular weight of tramadol HCl is 299.8.
- It is a white, bitter, crystalline and odorless powder that is readily soluble in water and ethanol and has a pKa of 9.41.
- The n-octanol/water log partition coefficient (logP) is 1.35 at pH 7.
- tramadol hcl extended-release tablets contain 100, 200 or 300 mg of tramadol HCl in an extended-release formulation.
The tablets are white to off-white in color and contain the inactive ingredients ethylcellulose, dibutyl sebacate, polyvinyl pyrrolidone, sodium stearyl fumarate, colloidal silicon dioxide, and polyvinyl alcohol.
- (tramadol hydrochloride/acetaminophen) Tablets combines two analgesics, tramadol 37.5 mg and acetaminophen 325 mg.
The chemical name for acetaminophen is N-acetyl-p-aminophenol.
- The molecular weight of acetaminophen is 151.17.
- Acetaminophen is an analgesic and antipyretic agent which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste.
- tablets contain 37.5 mg tramadol hydrochloride and 325 mg acetaminophen and are light yellow in color.
Inactive ingredients in the tablet are powdered cellulose, pregelatinized corn starch, sodium starch glycolate, corn starch, magnesium stearate, hypromellose, polyethylene glycol, polysorbate 80, titanium dioxide, iron oxide, and carnauba wax.
What is the most important information the patient should know about tramadol ?
he should not take tramadol if he is allergic to it ,if he has ever been addicted to drugs or alcohol, or if he has ever attempted suicide .
- he has not to take tramadol while he is intoxicated (drunk) or taking any of the following: alcohol or street drugs, narcotic pain medicine, sedatives or tranquilizers, or medicine for depression, anxiety, or mental illness.
- Tramadol may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.
- not to crush the tramadol tablet .
- This medicine is for oral (by mouth) use only.
- Powder from a crushed tablet should not be inhaled or diluted with liquid and injected into the body. Using this medicine by inhalation or injection may be fatal
- it can be taken with or without eating
و يفضل ياخد الجرعات التاليه بنفس الوضع من حيث الاكل و عدمه
Reference: FDA Prescribing Information
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