Abimol
Active constituent : paracetamol
Dosage forms : Tablets – Syrup - Suppositories.
Composition :
Each dosage unit contains: Tablet Syrup(5 ml) Suppository
Paracetamol 500 mg 150 mg 300 mg
Indication:
Analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine and tension headaches, toothache.. backache, rheumatic and muscle pains dysmenorrhoea , sore throat, and for relieving the fever, aches and pains of colds and flu. Also recommended for the symptomatic relief of pain due to non-serious arthritis .
Dosage & Administration:
Adults:
One to two tablets every 4 to 6 hours up to four times daily as required. Maximum daily dose is 4000 mg. Do not take more than 8 tablets in 24 hours. Do not take more frequently than every four hours
Children:
Children should not be given abimol for more than 3 days without consulting a doctor. No more than 4 doses to be taken in any 24 hour period. The maximum daily dose is 6Omg/kg 6-12 years: Half to one tablet three or four times daily as required.
1-6 years: 5 to 10 ml of the liquid suspension. Dose may he repeated after 4 hours.
3 months to less than 1 year: 2.5 to 5 ml of the liquid suspension. Dose may be repeated after 4 hours.
Less than 3 months: 2.5ml of the liquid suspension may be administered to infants who develop pyrexia after vaccination at 2 months of age. If necessary, a second dose can be given 4-6 hours later. If pyrexia persists after the second dose, medical attention is required.
Abimol should not be used with Other paracetamol containing products.
Contra-Indications:
Abimol is contraindicated in patients with hypersensitivity to paracetamol or excipients.
Side Effects:
Paracetamol has been widely used and, when taken at the usual recommended dosage, side effects are mild and infrequent and reports of adverse reactions are rare.
Skin rash and other allergic reactions occur rarely.
In patients sensitive to aspirin or other NSAIDs, aggravation of bronchospasm has been reported.
Most reports of adverse reactions to paracetamol relate to overdose with the drug
Isolated cases of blood dyscrasia, thromboeytopenic purputa. haemolytic anaemia and agranulocytosrs have been recorded. Chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year and liver damage has been reported after daily ingestion of excessive amounts for shorter periods.
Nephrotoxic effects following therapeutic doses of paracetamol are uncommon.
Over dose & treatment:
Potentially fatal liver damage is likely in adults who have taken 15g or more of paracetamol. As little as 10 g may lead to liver necrosis. Patients taking enzyme-inducing drugs or with a history of alcoholism may have an increased susceptibility.
Symptoms of paracetarn over dosage: in the first 24 hours are pallor, nausea, vomiting, diarrhoea. anorexia, abdominal pain and increased sweating, liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, coma, and death. Acute renal failure with acute tubular necrosis may develop even in the absence of severe liver damage. Cardiac arrhythmia have been reported.
Prompt treatment is essential in the management of paracetamol over dosage. Any patient who has ingested about 7.5 g or more of paracetamol in the preceding 4 hours should undergo gastric lavage or induced emesis. Specific therapy with an antidote such as acetylcysteine or methionine may be necessary. Acetylcysteine may be given either intravenously or by mouth or methionine may be given by mouth within 10 -12 hours of ingestion of the overdose. Generally treatment is required if the blood-paracetamol concentration is higher than 200 mg/litre at 4 hours and 30 mg/litre at 15 hours following Ingestion
Determination of the concentration before 4 hours is not considered to give a reliable measurement. Administration of oral methionine or intravenous N-aectylcystiene which may have a beneficial effect up to at least 48 hours after the overdose, may be required. General supportive measures must be available. Liver function tests should be performed at 24 hour intervals for at least 96 hours post-ingestion if the plasma paracetamol concentration indicates a potential for hepatotoxicity. Renal and cardiac function should be monitored and supportive treatmen should be directed at maintaining fluid and electrolyte balance and correctnig hypo-glycaemia. Haemodialysis and haemoperfusion have been used with some success but peritoneal dialysis is ineffective.
Drug Interaction:
the anticoagulant effect of warfarin and other coumarins may be prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
Pregnancy & lactation:
Human and animal studies have not identified any risk to pregnancy or embryofoetal devetopment. Human studies have not identified any risk to lactation or the breast-fed offspring.
Precaution & Warnings:
Care is advised in the administration of paracetamol to patients with severe renal or hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease. Patients who are taking other potentially hepatotoxic drugs are at increased risk of paracetamol-induced hepatoluxicity.
Dosage forms : Tablets – Syrup - Suppositories.
Composition :
Each dosage unit contains: Tablet Syrup(5 ml) Suppository
Paracetamol 500 mg 150 mg 300 mg
Indication:
Analgesic and antipyretic, and is recommended for the treatment of most painful and febrile conditions, for example, headache including migraine and tension headaches, toothache.. backache, rheumatic and muscle pains dysmenorrhoea , sore throat, and for relieving the fever, aches and pains of colds and flu. Also recommended for the symptomatic relief of pain due to non-serious arthritis .
Dosage & Administration:
Adults:
One to two tablets every 4 to 6 hours up to four times daily as required. Maximum daily dose is 4000 mg. Do not take more than 8 tablets in 24 hours. Do not take more frequently than every four hours
Children:
Children should not be given abimol for more than 3 days without consulting a doctor. No more than 4 doses to be taken in any 24 hour period. The maximum daily dose is 6Omg/kg 6-12 years: Half to one tablet three or four times daily as required.
1-6 years: 5 to 10 ml of the liquid suspension. Dose may he repeated after 4 hours.
3 months to less than 1 year: 2.5 to 5 ml of the liquid suspension. Dose may be repeated after 4 hours.
Less than 3 months: 2.5ml of the liquid suspension may be administered to infants who develop pyrexia after vaccination at 2 months of age. If necessary, a second dose can be given 4-6 hours later. If pyrexia persists after the second dose, medical attention is required.
Abimol should not be used with Other paracetamol containing products.
Contra-Indications:
Abimol is contraindicated in patients with hypersensitivity to paracetamol or excipients.
Side Effects:
Paracetamol has been widely used and, when taken at the usual recommended dosage, side effects are mild and infrequent and reports of adverse reactions are rare.
Skin rash and other allergic reactions occur rarely.
In patients sensitive to aspirin or other NSAIDs, aggravation of bronchospasm has been reported.
Most reports of adverse reactions to paracetamol relate to overdose with the drug
Isolated cases of blood dyscrasia, thromboeytopenic purputa. haemolytic anaemia and agranulocytosrs have been recorded. Chronic hepatic necrosis has been reported in a patient who took daily therapeutic doses of paracetamol for about a year and liver damage has been reported after daily ingestion of excessive amounts for shorter periods.
Nephrotoxic effects following therapeutic doses of paracetamol are uncommon.
Over dose & treatment:
Potentially fatal liver damage is likely in adults who have taken 15g or more of paracetamol. As little as 10 g may lead to liver necrosis. Patients taking enzyme-inducing drugs or with a history of alcoholism may have an increased susceptibility.
Symptoms of paracetarn over dosage: in the first 24 hours are pallor, nausea, vomiting, diarrhoea. anorexia, abdominal pain and increased sweating, liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, coma, and death. Acute renal failure with acute tubular necrosis may develop even in the absence of severe liver damage. Cardiac arrhythmia have been reported.
Prompt treatment is essential in the management of paracetamol over dosage. Any patient who has ingested about 7.5 g or more of paracetamol in the preceding 4 hours should undergo gastric lavage or induced emesis. Specific therapy with an antidote such as acetylcysteine or methionine may be necessary. Acetylcysteine may be given either intravenously or by mouth or methionine may be given by mouth within 10 -12 hours of ingestion of the overdose. Generally treatment is required if the blood-paracetamol concentration is higher than 200 mg/litre at 4 hours and 30 mg/litre at 15 hours following Ingestion
Determination of the concentration before 4 hours is not considered to give a reliable measurement. Administration of oral methionine or intravenous N-aectylcystiene which may have a beneficial effect up to at least 48 hours after the overdose, may be required. General supportive measures must be available. Liver function tests should be performed at 24 hour intervals for at least 96 hours post-ingestion if the plasma paracetamol concentration indicates a potential for hepatotoxicity. Renal and cardiac function should be monitored and supportive treatmen should be directed at maintaining fluid and electrolyte balance and correctnig hypo-glycaemia. Haemodialysis and haemoperfusion have been used with some success but peritoneal dialysis is ineffective.
Drug Interaction:
the anticoagulant effect of warfarin and other coumarins may be prolonged regular daily use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
Pregnancy & lactation:
Human and animal studies have not identified any risk to pregnancy or embryofoetal devetopment. Human studies have not identified any risk to lactation or the breast-fed offspring.
Precaution & Warnings:
Care is advised in the administration of paracetamol to patients with severe renal or hepatic impairment. The hazard of overdose is greater in those with non-cirrhotic alcoholic liver disease. Patients who are taking other potentially hepatotoxic drugs are at increased risk of paracetamol-induced hepatoluxicity.