Brufen
Active constituent : Ibuprofen.
Dosage forms : Tablet & suspension.
Composition :
200 mg Tablet Each sugarcoated tablet contains 200 mg ibuprofen
400 mg Tablet Each sugarcoated tablet contains 400 mg ibuprofen
600 mg Tablet Each filmcoated tablet contains 600 mg ibuprofen
Paediatric Suspension Each 5 mL of suspension contains 100 mg ibuprofen
Pharmacokinetics: Brufen is well absorbed on oral administration. An oral dose taken on an empty stomach produced peak serum levels after three quarters of an hour. Absorption was slower and peak serum levels lower after food. Excretion is rapid with no evidence of accumulation.
Indications: Brufen is indicated for its analgesic and anti-inflammatory effect in the treatment of rheumatoid arthritis. Brufen is indicated in the treatment of non-articular rheumatism including fibrositis. Brufen is indicated in peri-articular conditions such as frozen shoulder (capsulitis), bursitis, tendinitis, tenosynovitis and low-back pain. Brufen can also be used in soft-tissue injuries such as sprains and strains. Brufen is also indicated for its analgesic effect in the relief of mild to moderate pain such as dysmenorrhoea, dental, post-episiotomy pain and post-partum pain. Brufen may also be used as an antipyretic.
Dosage and Administration:
Adults: The recommended dosage of Brufen is 1200 mg daily in divided doses. To relieve early morning stiffness, the first dose of the day can be given immediately after the patient awakes.
For the relief of mild to moderate pain the following doses are recommended:
Dysmenorrhoea - 1200 mg per day in three divided doses. In cases of dental or post-episiotomy pain an initial dose of 800 mg may be given. The total daily dose of Brufen should not exceed 2400 mg. Once the acute phase has been brought under control, it is normal practice to revert to a maintenance dosage.
Acute gout: 2400 mg daily either as 800 mg 8 hourly or 600 mg 6 hourly until the acute symptoms have been relieved. If the acute symptoms do not resolve within three days, consult a doctor.
Children: In Rheumatoid Arthritis, the total daily dosage of Brufen is 20 mg/kg of body mass given in divided doses.
Safety in children under one year of age has not been proven.
Pain: Initial dose 5 mg/kg of bodyweight.
A second dose of 5 mg/kg may be given after 2 hours if pain is not controlled, thereafter 5 mg/kg every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If pain persists for more than 7 days, consult your doctor.
Fever: 5 mg/kg of bodyweight every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If fever persists for more than 3 days, consult your doctor.
Do not give to children less than 7 kg or 1 year of age, except on the advice of your doctor.
Contraindications:
-Brufen should not be given to patients with peptic ulceration. -The safety of Brufen in pregnancy has not been established.
-Hypersensitivity to Ibuprofen, aspirin or any other non-steroidal anti-inflammatory agent.
Side Effects:
The most frequent side effects occurring with Ibuprofen are gastro-intestinal disturbances; reactions range from abdominal discomfort, nausea and vomiting, and abdominal pain to serious gastro-intestinal bleeding or activation of peptic ulcer.
CNS-related side effects include headache, dizziness, nervousness, tinnitus, depression, drowsiness, and insomnia. Hypersensitivity reactions may occur less frequently and include fever and rashes. Hepatotoxicity and aseptic meningitis which occur less frequently may also be hypersensitivity reactions. Ibuprofen can provoke bronchospasm in patients with asthma. Ibuprofen may cause cystitis and haematuria. They may also cause acute renal failure, interstitial , nephritis,and nephrotic syndrome.
Other side effects include anaemias, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, abnormalities in liver function tests and blurred vision
Drug Interactions:
Care should be taken in patients treated with any of the following drugs as interactions have been reported in some patients:
Antihypertensives, beta-blockers and diuretics: NSAIDs may reduce the effect of anti-hypertensives, such as beta-blockers and diuretics.
Diuretics can also increase the risk of nephrotoxicity of NSAIDs.
Cardiac glycosides: NSAIDs may exacerbate cardiac failure and increase plasma cardiac glycoside levels.
Lithium: Decreased elimination of lithium.
Other analgesics and cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs, including Cox-2 inhibitors, as this may increase the risk of adverse effects
Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding with NSAIDs.
Anticoagulants: NSAIDs may enhance the effects of anticoagulants, such as warfarin
Precautions:
Brufen should be given with care to patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease, a history of peptic ulceration, and in liver or renal failure. Care is required in those who are also receiving coumarin anticoagulants. Patients who are sensitive to aspirin or other NSAIDs should generally not be given Ibuprofen.
Ibuprofen should be discontinued in patients who experience blurred or diminished vision, or changes in colour vision. Patients with collagen disease may be at increased risk of developing aseptic meningitis.
Dosage forms : Tablet & suspension.
Composition :
200 mg Tablet Each sugarcoated tablet contains 200 mg ibuprofen
400 mg Tablet Each sugarcoated tablet contains 400 mg ibuprofen
600 mg Tablet Each filmcoated tablet contains 600 mg ibuprofen
Paediatric Suspension Each 5 mL of suspension contains 100 mg ibuprofen
Pharmacokinetics: Brufen is well absorbed on oral administration. An oral dose taken on an empty stomach produced peak serum levels after three quarters of an hour. Absorption was slower and peak serum levels lower after food. Excretion is rapid with no evidence of accumulation.
Indications: Brufen is indicated for its analgesic and anti-inflammatory effect in the treatment of rheumatoid arthritis. Brufen is indicated in the treatment of non-articular rheumatism including fibrositis. Brufen is indicated in peri-articular conditions such as frozen shoulder (capsulitis), bursitis, tendinitis, tenosynovitis and low-back pain. Brufen can also be used in soft-tissue injuries such as sprains and strains. Brufen is also indicated for its analgesic effect in the relief of mild to moderate pain such as dysmenorrhoea, dental, post-episiotomy pain and post-partum pain. Brufen may also be used as an antipyretic.
Dosage and Administration:
Adults: The recommended dosage of Brufen is 1200 mg daily in divided doses. To relieve early morning stiffness, the first dose of the day can be given immediately after the patient awakes.
For the relief of mild to moderate pain the following doses are recommended:
Dysmenorrhoea - 1200 mg per day in three divided doses. In cases of dental or post-episiotomy pain an initial dose of 800 mg may be given. The total daily dose of Brufen should not exceed 2400 mg. Once the acute phase has been brought under control, it is normal practice to revert to a maintenance dosage.
Acute gout: 2400 mg daily either as 800 mg 8 hourly or 600 mg 6 hourly until the acute symptoms have been relieved. If the acute symptoms do not resolve within three days, consult a doctor.
Children: In Rheumatoid Arthritis, the total daily dosage of Brufen is 20 mg/kg of body mass given in divided doses.
Safety in children under one year of age has not been proven.
Pain: Initial dose 5 mg/kg of bodyweight.
A second dose of 5 mg/kg may be given after 2 hours if pain is not controlled, thereafter 5 mg/kg every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If pain persists for more than 7 days, consult your doctor.
Fever: 5 mg/kg of bodyweight every 4 - 6 hours. DO NOT EXCEED 20 mg/kg of bodyweight per day. If fever persists for more than 3 days, consult your doctor.
Do not give to children less than 7 kg or 1 year of age, except on the advice of your doctor.
Contraindications:
-Brufen should not be given to patients with peptic ulceration. -The safety of Brufen in pregnancy has not been established.
-Hypersensitivity to Ibuprofen, aspirin or any other non-steroidal anti-inflammatory agent.
Side Effects:
The most frequent side effects occurring with Ibuprofen are gastro-intestinal disturbances; reactions range from abdominal discomfort, nausea and vomiting, and abdominal pain to serious gastro-intestinal bleeding or activation of peptic ulcer.
CNS-related side effects include headache, dizziness, nervousness, tinnitus, depression, drowsiness, and insomnia. Hypersensitivity reactions may occur less frequently and include fever and rashes. Hepatotoxicity and aseptic meningitis which occur less frequently may also be hypersensitivity reactions. Ibuprofen can provoke bronchospasm in patients with asthma. Ibuprofen may cause cystitis and haematuria. They may also cause acute renal failure, interstitial , nephritis,and nephrotic syndrome.
Other side effects include anaemias, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, abnormalities in liver function tests and blurred vision
Drug Interactions:
Care should be taken in patients treated with any of the following drugs as interactions have been reported in some patients:
Antihypertensives, beta-blockers and diuretics: NSAIDs may reduce the effect of anti-hypertensives, such as beta-blockers and diuretics.
Diuretics can also increase the risk of nephrotoxicity of NSAIDs.
Cardiac glycosides: NSAIDs may exacerbate cardiac failure and increase plasma cardiac glycoside levels.
Lithium: Decreased elimination of lithium.
Other analgesics and cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs, including Cox-2 inhibitors, as this may increase the risk of adverse effects
Corticosteroids: Increased risk of gastrointestinal ulceration or bleeding with NSAIDs.
Anticoagulants: NSAIDs may enhance the effects of anticoagulants, such as warfarin
Precautions:
Brufen should be given with care to patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease, a history of peptic ulceration, and in liver or renal failure. Care is required in those who are also receiving coumarin anticoagulants. Patients who are sensitive to aspirin or other NSAIDs should generally not be given Ibuprofen.
Ibuprofen should be discontinued in patients who experience blurred or diminished vision, or changes in colour vision. Patients with collagen disease may be at increased risk of developing aseptic meningitis.